Michy Batshuayi, Rodrigo Moreno and Goncalo Guedes all start for Valencia at Manchester United, while Real Madrid hand a debut to Sergio Reguilon.
Valencia are not holding back as they name their three prized attackers for the trip to Old Trafford, although Kevin Gameiro is sacrificed, despite firing Los Che to their first win of the season over the weekend.
Jose Gaya and Cristiano Piccini also return from their respective injuries to take both full-back positions, but Santi Mina is sidelined.
United, meanwhile, have gone three games without a victory to heap the pressure on manager Jose Mourinho, who fields stalwarts Marouane Fellaini and Alexis Sanchez as opposed to the likes of Fred and Anthony Martial.
As for Madrid, Keylor Navas starts in goal, Castilla starlet Reguilon comes in at left-back and Lucas Vazquez is handed a rare chance on the right wing, while Dani Ceballos is rewarded for his Derbi display.
Los Blancos are playing at Luzhniki Stadium, where France beat Croatia 4-2 to win the 2018 World Cup.
Manchester United: De Gea; Valencia, Smalling, Bailly, Shaw; Fellaini, Matic, Pogba; Alexis, Lukaku, Rashford
Valencia: Neto; Piccini, Gabriel, Garay, Gaya; Parejo, Coquelin, Kondogbia, Guedes; Batshuayi, Rodrigo
Referee: Vincic (SLO)
CSKA Moscow: Akinfeev; Rodrigo, Chernov, Nababkin; Fernandes, Bijol, Akhmetov, Oblyakov (Kyrnats 90); Dzagoev (Efremov 65), Chalov (Sigurdsson 78), Vlasic
Real Madrid: Keylor; Carvajal, Varane, Nacho, Reguilon; Ceballos, Casemiro, Kroos; Vazquez, Benzema, Asensio
Referee: Hategan (ROM)