Cristiano Ronaldo is back for Real Madrid against APOEL tonight, while Liverpool name Philippe Coutinho as a substitute for their visit of Sevilla.
Ronaldo returns from his five-match ban for shoving a referee, but Marco Asensio is absent after suffering a freak infection from shaving his leg.
Elsewhere for Madrid, Nacho Fernandez continues at centre-back, despite Raphael Varane being a substitute, and Toni Kroos makes way for Mateo Kovacic in the middle of the park.
Both sides last met in the Champions League quarter-finals five years ago, when Los Blancos demolished the Cypriots 8-2 on aggregate.
Sevilla, on the other hand, bring in Simon Kjaer, Nicolas Pareja, Guido Pizarro and Joaquin Correa from their 3-0 win against Eibar at the weekend.
Coutinho also features in Liverpool's matchday squad for the first time this season after his failed transfer to Barcelona.
The Andalusians came out on top in their previous meeting with the Reds – the 2016 Europa League Final.
Real Madrid: Keylor; Carvajal, Nacho, Ramos, Marcelo; Modric, Casemiro, Kovacic; Isco; Bale, Ronaldo
APOEL: Waterman; Vouros, Rueda, Carlao, Lago; Sallai, Morais, Ebecilio, Vinicius, Aloneftis; De Camargo
Referee: Bastien (FRA)
Liverpool: Karius; Gomez, Lovren, Matip, Moreno; Wijnaldum, Can, Henderson; Salah, Mane, Firmino
Sevilla: Sergio Rico; Mercado, Pareja, Kjaer, Escudero; Pizarro, N'Zonzi; Jesus Navas, Banega, J Correa; Ben Yedder
Referee: Makkelie (NED)