Real Madrid go with Lucas Vazquez and Marco Asensio in attack against Barcelona, who switch to three at the back and Andre Gomes on the left.
Asensio's wonder strike sealed Madrid a 3-1 away advantage in the Supercopa last Sunday, and the winger is rewarded with a starting spot ahead of Isco, which also marks a return to 4-3-3 for Los Blancos.
Elsewhere, Vazquez replaces Gareth Bale to take his place on the right wing, while Casemiro makes way for Luka Modric, who is back from suspension.
Finally for the capital giants, Cristiano Ronaldo begins his five-match ban for pushing the referee at Camp Nou.
Barca, meanwhile, adopt a 3-4-3 formation, with Javier Mascherano coming into defence and Gomes presumably on the left of their attacking trident.
However, there is no place in the Catalans' squad for new boy Paulinho.
Real Madrid: Keylor; Carvajal, Varane, Ramos, Marcelo; Modric, Kovacic, Kroos; Vazquez, Benzema, Asensio
Subs: Casilla, Nacho, Bale, Casemiro, Theo, Isco, Ceballos
Barcelona: Ter Stegen; Pique, Mascherano, Umtiti; Sergi Roberto, Rakitic, Busquets, Alba; Messi, Suarez, Gomes
Subs: Cillessen, Semedo, Denis, Deulofeu, Alcacer, Digne, Vidal
Referee: Sanchez Martinez