Real Madrid go with Isco in a 4-3-1-2 against Bayern Munich this evening as Josema Gimenez is a surprise starter in midfield for Atletico at Leicester City.
Gareth Bale's failure to recover from a calf injury in time allows Isco to keep his place in the Madrid team after his match-winning display at Sporting Gijon over the weekend, although his inclusion prompts a change in formation.
Bayern, on the other hand, welcome back key duo Mats Hummels and Robert Lewandowski, the pair having missed the first leg in Germany with knocks.
Lewandowski is said to be a long-time target for Los Blancos and scored a hat-trick against them for Borussia Dortmund in the 2012-13 Champions League semi-finals.
Atletico, meanwhile, opt to shut up shop in midfield by naming centre-back Gimenez alongside enforcer Gabi, with Yannick Carrasco moving alongside Antoine Griezmann up top.
However, Los Colchoneros have Fernando Torres and recent returnee Kevin Gameiro if they wish to throw on some attacking firepower.
Finally, Leicester are able to call on Wes Morgan in central defence again after the captain passed a late fitness test to prove his recovery from a back problem.
Madrid lead Bayern 2-1 in their Champions League quarter-final tie, while Atleti take a 1-0 lead to the King Power Stadium.
Real Madrid: Keylor; Carvajal, Nacho, Ramos, Marcelo; Modric, Casemiro, Kroos; Isco; Benzema, Ronaldo
Bayern Munich: Neuer; Lahm, Boateng, Hummels, Alaba; Vidal, Alonso, Thiago; Robben, Lewandowski, Ribery
Referee: Kassai (HUN)
Leicester City: Schmeichel; Simpson, Benalouane, Morgan, Fuchs; Mahrez, Ndidi, Drinkwater, Albrighton; Okazaki, Vardy
Atletico Madrid: Oblak; Juanfran, Godin, Savic, Filipe; Koke, Gabi, Gimenez, Saul; Carrasco, Griezmann
Referee: Rocchi (ITA)