Robert Lewandowski is missing for Bayern Munich against Real Madrid tonight, while Leicester City are without captain Wes Morgan at Atletico.
Lewandowski has failed to recover in time from a shoulder injury, sustained against former club Borussia Dortmund last weekend, while Morgan is struggling with a back problem.
Madrid are down to barebones in central defence, with Nacho Fernandez partnering Sergio Ramos due to Pepe and Raphael Varane suffering from setbacks.
Bayern are also without a first-choice centre-back in Mats Hummels, who picked up an ankle injury against Dortmund.
Midfielders Toni Kroos and Xabi Alonso face their old teams, having played for them when the two sides last met competitively in the 2014 semi-finals.
Sime Vrsaljko and Kevin Gameiro, meanwhile, remain Atleti’s only absentees against a Leicester side that eliminated Sevilla in the previous round.
Bayern Munich: Neuer; Lahm, Boateng, Javi Martinez, Alaba; Alonso, Vidal, Thiago; Robben, Muller, Ribery
Real Madrid: Keylor; Carvajal, Nacho, Ramos, Marcelo; Modric, Casemiro, Kroos; Bale, Benzema, Ronaldo
Referee: Rizzoli (ITA)
Atletico Madrid: Oblak; Juanfran, Godin, Savic, Filipe; Gabi, Koke, Saul, Carrasco; Griezmann, Torres
Leicester City: Schmeichel; Simpson, Benalouane, Huth, Fuchs; Mahrez, Ndidi, Drinkwater, Albrighton; Okazaki; Vardy
Referee: Eriksson (SWE)