Atletico Madrid goalkeeper Jan Oblak could make his first start since December after recovering from a dislocated shoulder.
The 24-year-old had to undergo surgery after the injury sustained in a defeat to Villarreal ten weeks ago with Miguel Angel Moya deputising in his place.
"We'll watch him train and decide after that," Atleti boss Diego Simeone said ahead of the game.
"Leverkusen are a very strong side and Javier Hernandez is in fine form. We're playing a team with great intensity, but we have great intensity too."
Bayer boss Roger Schmidt also believes the former Manchester United striker Hernandez will be key
"They have an exceptional squad and we'll have to do very well to beat them," added Schmidt.
"He is in amazing form and has played very well in every game so far this year.
"It is hugely important when you play at this level to have players with such self-confidence and that kind of scoring efficiency."