Andres Iniesta is back for Barcelona, who drop Rafinha, while Alvaro Morata and Toni Kroos stay out of the Real Madrid squad.
Iniesta is able to play for the first time in over a month after recovering from a knee injury, but Jeremy Mathieu’s calf relapse rules him out.
Rafinha, meanwhile, joins Aleix Vidal and Jordi Masip in being left out, despite the midfielder not carrying any fitness problems.
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On the other hand, Madrid are still without Morata, whose Achilles tendon remains an issue, and Kroos, although the German’s broken toe has since healed.
Danilo and Fabio Coentrao are also off the list as the full-backs are struggling with muscle strains.
Today’s referee at Camp Nou is Carlos Clos Gomez, who will be making his first appearance in a Clasico.
Barcelona: Ter Stegen, Cillessen; Pique, Rakitic, Sergio, Denis, Arda, Iniesta, Suarez, Messi, Neymar, Mascherano, Alcacer, Alba, Digne, Sergi, Gomes, Umtiti
Real Madrid: Navas, Casilla and Yanez; Carvajal, Pepe, Ramos, Varane, Nacho, Marcelo; James, Casemiro, Kovacic, Modric, Asensio, Isco; Ronaldo, Benzema, Vazquez, Mariano
Referee: Clos Gomez
