Nuno Santo has sprung a surprise in the Valencia XI to play Zenit St Petersburg, naming teenager Rafa Mir on the left of the front three.
Sofiane Feghouli takes the spot on the right wing with Paco Alcacer through the middle, and the midfield trio is made up of Enzo Perez, Dani Parejo and Andre Gomes.
Jaume Domenech continues in goal behind a back four of Joao Cancelo, Ruben Vezo, Aymen Abdennour and Jose Gaya.
Zenit have the in-form Hulk as part of their XI, with Artyom Dzyuba also starting. Axel Witsel is in midfield, joined by captain Danny and former Racing Santander and Real Madrid centre-back Ezequiel Garay marshals the defence.
Zenit are unbeaten in the Champions League thus far and top Group H, leading Los Che by six points.
Valencia are second ahead of Gent but lost to the Belgians in their last outing and were beaten in the first round of games by Zenit, going down 3-2 at Mestalla.
Zenit St Petersburg: Lodygin; Smolnikov, Garay, Lombaerts, Criscito; Neto, Witsel; Shatov, Danny, Hulk; Dzyuba
Subs: Kerzhakov, Zuev, Ryazantsev, Yusupov, Troyanov, Evseev, Dolgov
Valencia: Domenech; Cancelo, Vezo, Abdennour, Gaya; Perez, Parejo, Gomes; Feghouli, Alcacer, Mira
Subs: Ryan, Santos, Orban, Danilo, Javi Fuego, De Paul, Santi Mina
Referee: Moen [NOR]