Tottenham would consider including Isco in any proposed operation that takes Christian Eriksen to Real Madrid, say reports in Spain.
A fresh report in El Desmarque claim that Bayern Munich are also closely following the situation of the Spain international, but Spurs may hold a negotiating advantage with Los Blancos.
Zinedine Zidane is thought to be a keen admirer of Isco but equally would not block a transfer should a big-money offer come in from elsewhere.
Juventus, Milan and Manchester City have been among the clubs linked to the playmaker but no interest has ever been formalised with an offer.
The 26-year-old had been frozen out of the starting XI by previous Madrid boss Santiago Solari – not starting a match across La Liga or the Champions League under the Frenchman’s predecessor.
Isco has a contract at the Santiago Bernabeu until 2021 but found the net just three times in a mere 11 La Liga starts last season, with his future appearing to be in the balance.
It appears unlikely that the former Malaga playmaker will be a regular in Madrid’s line-up this season while any sale would be a reluctant one.
