Mateo Kovacic and Borja Mayoral start for Real Madrid against Borussia Dortmund as Sevilla are full-strength for their clash with NK Maribor.
Madrid have already qualified for the Champions League last 16, albeit as Group H runners-up, making tonight's visit of Dortmund a dead rubber, although the Germans may need to win in order to secure a Europa League place.
Consequently, only Raphael Varane, Sergio Ramos, Casemiro, Isco and Cristiano Ronaldo are Los Blancos' first-teamers, with Kovacic and Vazquez joined from the periphery by Nacho Fernandez, Theo Hernandez and Lucas Vazquez.
Dani Carvajal, Gareth Bale and Toni Kroos have not been included in the matchday squad, but Marco Asensio is back among the substitutes, alongside Karim Benzema, Luka Modric and Marcelo.
Sevilla, on the other hand, must beat Maribor to qualify for the knockout stages, although they can still progress with a defeat if Liverpool beat Spartak Moscow.
Real Madrid: Keylor; Nacho, Varane, Ramos, Theo; Kovacic, Casemiro, Isco; Vazquez, Mayoral, Ronaldo
Borussia Dortmund: Burki; Sokratis, Subotic, Schmelzer; Bartra, Sahin, Dahoud, Guerreiro; Pulisic, Aubameyang, Kagawa
Referee: Kralovec (CZE)
NK Maribor: Handanovic; Milec, Suler, Bilong, Viler; Bajde, Pihler, Vrhovic, Kabha, Bohar; Tavares
Sevilla: Sergio Rico; Mercado, Kjaer, Lenglet, Escudero; Krohn-Dehli, Pizarro, Banega; Sarabia, Ben Yedder, Joaquin Correa
Referee: Hategan (ROM)