Fernando Torres returns to Chelsea with Atletico Madrid, while Barcelona rest Lionel Messi for the second Champions League match in a row.
Messi is joined by fellow first-teamers Marc-Andre ter Stegen, Sergio Busquets and Jordi Alba on Barca’s bench, which is completed by Sergi Roberto, Gerard Deulofeu and Paulinho.
Tonight’s game is a dead rubber for the Blaugrana, given they have already qualified for the last 16 as group winners, although Sporting will look to cause a shock at Camp Nou and hope Juventus lose to Olympiacos.
Atleti, meanwhile, drop Diego Godin, Angel Correa and Kevin Gameiro for Stefan Savic, Lucas Hernandez and Torres, who has yet to score in La Liga or the Champions League this season.
Los Colchoneros must beat Chelsea and bank on Roma failing to beat Qarabag as they are just one goal worse off to the Italians and possess a superior head-to-head record.
Barcelona: Cillessen; Semedo, Pique, Vermaelen, Digne; Rakitic, Gomes, Denis; Vidal, Suarez, Alcacer
Sporting CP: Rui Patricio; Piccini, Coates, Mathieu, Ristovski; Battaglia, William; Bruno Cesar, Acuna, Bruno Fernandes; Alan Ruiz
Referee: Thomson (SCO)
Chelsea: Courtois; Azpilicueta, Christensen, Cahill; Zappacosta, Kante, Cesc, Bakayoko, Kante; Hazard, Morata
Atletico Madrid: Oblak; Gimenez, Savic, Lucas, Filipe; Koke, Thomas, Gabi, Saul; Torres, Griezmann
Referee: Makkelie (NED)