Real Madrid captain Sergio Ramos has joined Gareth Bale, Keylor Navas and Matteo Kovacic in not travelling to APOEL Nicosia.
Zinedine Zidane’s side will progress to the last 16 of the Champions League with a victory despite picking up only one point from two games against group leaders Tottenham Hotspur.
Ramos sustained a broken nose in Saturday’s derby draw with Atletico Madrid while the other three players are yet to return from injury layoffs.
Madrid beat the Cypriot side 3-0 at the Bernabeu in the first group game, with Cristiano Ronaldo netting twice and Ramos also getting on the scoresheet.
Real Madrid squad:Casilla, Moha, Carvajal, Marcelo, Vallejo, Varane, Nacho, Theo, Achraf, Kroos, Modric, Casemiro, Llorente, Asensio, Isco, Ceballos, Benzema, Ronaldo, Lucas Vazquez, Mayoral