Atletico Madrid have confirmed Kevin Gameiro, Nicolas Gaitan and Miguel Angel Moya have all picked up injuries.
Los Rojiblancos travel to Malaga on Saturday but striker Gameiro (right of picture) and goalkeeper Moya both have thigh problems while Gaitan has arthritis in his toe, leaving Diego Simeone with only 16 fit first-team squad members for the clash.
"An MRI scan was carried out on Moya on Thursday after the injury he suffered in training last Wednesday,” read an Atleti statement.
"The medical results show that our goalkeeper has suffered a muscle injury in the femoral biceps of the left thigh. He will face physiotherapy and rehabilitation treatment.
"Argentine midfielder Nico Gaitan is suffering from arthritis in the metatarsophalangeal joint of the first toe of his left foot. As with Moya, he will undergo physiotherapy treatment and rehabilitation.
"Finally, Kevin Gameiro felt discomfort after the friendly match played in Paris between the national teams of France and Spain. Our striker has undergone an MRI scan that confirms that he is suffering from tendinitis in the adductor of his left thigh.
"He will also be put in the hands of our physios in order to return as soon as possible."