Luciano Vietto gets the nod to partner Antoine Griezmann as Atletico Madrid look to win Champions League Group C at Benfica.
Benfica top the table ahead of the last round of games but they and Atleti are level on 10 points, so the fixture at the Stadium of Light amounts to a play-off to decide the group winner.
A draw would be enough for Benfica after their 2-1 win at Vicente Calderon, so Atleti have to win and Vietto and Griezmann spearhead the attack with that in mind.
Yannick Ferreira-Carrasco and Koke also start, with Saul Niguez and Gabi rounding out Diego Simeone’s midfield.
Jan Oblak keeps goal behind a back four of Juanfran, Stefan Savic, Diego Godin and Filipe Luis.
Benfica: Julio Cesar; Lisandro Lopez, Jardel, Fejsa, Eliseu; Andre Almeida, Renato Sanches, Guedes; Gaitan, Jonas, Pizzi
Subs: Ederson, Lindelof, Samaris, Carcela-Gonzalez, Jimenez, Mitroglu, Talisca
Atletico Madrid: Oblak, Juanfran, Savic, Godin, Filipe Luis; Saul, Koke, Gabi, Carrasco; Vietto, Griezmann
Subs: Moya, Siqueira, Gimenez, Oliver, Correa, Partey, Torres