Xavi Hernandez gets a Camp Nou send-off and Thomas Vermaelen is given his Barcelona debut as relegation candidates Deportivo hope to spoil the party.
In similar vein to Steven Gerrard for Liverpool last week, the midfielder will be able to bid farewell to the Catalan faithful ahead of his summer move to Qatari club Al Sadd.
Another key inclusion is that of Vermaelen, who finally makes his first official appearance for Barca in the heart of defence since arriving from Arsenal over eight months ago.
Other notable additions see Jordi Masip handed a rare start in goal, while the likes of Adriano, Rafinha and Sergi Roberto are given opportunities to showcase their talents.
Barca have already sewn up La Liga heading into this evening’s final round, meaning the onus is now on Depor to see out the great escape, which can be confirmed with a shock victory.
Barcelona: Masip; Adriano, Bartra, Vermaelen, Mathieu; Sergi Roberto, Xavi, Rafinha; Pedro, Messi, Neymar
Subs: Douglas, Montoya, Munir, Iniesta, Mascherano, Bravo, Alba
Deportivo: Fabricio; Laure, Lopo, Sidnei, Canella; Alex, Borges; Lucas, Dominguez, Salomao; Cavaleiro
Subs: Lux, Rodriguez, Insua, Costa, Medunjanin, Riera, Postiga
Referee: Clos Gomez