Diego Forlan returns to the Uruguay XI as Luis Suarez’s misses his first international after suspension against Colombia.
This is only the second time these nations have faced off in a World Cup, the other being in 1962 when Uruguay fought back from a goal down to win 2-1. However, that was a group phase game and neither of them progressed to the knockouts.
And the Celestes play in Rio without their star man after he was handed a four-month ban for the bite on Giorgio Chiellini.
Breakout star of the tournament James Rodriguez starts alongside Juan Cuadrado and Jackson Martinez up top.
Colombia: Ospina; C Zuniga, C Zapata, Yepes, Armero; Aguilar, C Sanchez;Cuadrado, James Rodriguez, Jackson Martinez; Gutierrez
Uruguay: Muslera; Caceres, Godin, Gimenez, A Pereira; Gonzalez, ArevaloRios, Rodriguez, Maxi Pereira; Cavani, Forlan