Sevilla suffered a surprise 2-1 defeat at Leganes just five days after reaching the quarter finals of the Champions League.
Unai Bustinza and Javi Eraso scored either side of the break to put the hosts in control before Sevilla had Pablo Sarabia sent off for two bookable offences.
Miguel Layun pulled a late goal back for Vincenzo Montella’s side but it wasn’t enough to stop them slipping to their sixth defeat in 12 league games under his management.
The Andalucian club have slipped to sixth in the league standings with Girona and city rivals Real Betis now only two points adrift of them in the table.
Asier Garitano’s Leganes have moved up four places to 12th, and have put to bed any lingering doubts about a relegation battle.