Luis Enrique names an experimental Spain XI, which includes Raul Albiol, Suso and Paco Alcacer, against Wales this evening.
With no Dani Carvajal, Jordi Alba, Isco or Diego Costa in the squad and both Gerard Pique and Andres Iniesta long gone, several peripheral figures are given run-outs in Cardiff.
Consequently, Cesar Azpilicueta comes in at right-back, with Jose Gaya staying on the left, and Albiol partners Sergio Ramos in central defence, while Alcacer and Suso flank lone striker Alvaro Morata.
Wales, for their part, are without talisman Gareth Bale, who is out with muscle fatigue, so Arsenal mdifielder Aaron Ramsey is pushed into attack.
La Roja are unbeaten in four of their five previous meetings with Wales, although they lost 3-0 the last time they faced the Euro 2016 semi-finalists, back in April 1985.
Wales: Hennessey; Gunter, Davies, Williams, Roberts, John, Allen, Ampadu, Wilson, Ramsey, Vokes
Spain: De Gea; Azpilicueta, Ramos, Albiol, Gaya; Saul, Rodri, Ceballos; Suso, Morata, Alcacer
Referee: Taylor (ENG)