Gerard Pique starts and Alvaro Odriozola and Rodrigo Moreno make their full Spain debuts against Albania in tonight's 2018 World Cup qualifier.
Pique is likely to be given a mixed reception by Spain fans after his support for last weekend's Catalan referendum, which resulted in 100s of injuries and an institutional crisis.
Odriozola, meanwhile, is rewarded for his breakthrough start to the season with Real Sociedad, whereas Rodrigo makes his first senior appearance in three years after firing four goals for Valencia.
La Roja will all-but-book their place in Russia next summer with victory over Albania, who still have an unlikely chance of qualifying for the playoffs at Italy's expense.
Spain: De Gea; Odriozola, Pique, Ramos, Alba; Koke, Saul, Thiago; Silva, Rodrigo, Isco
Subs: Asensio, Nacho, Azpilicueta, Reina, Pedro, Monreal, Viera, Aspas, Callejon, Illarramendi, Kepa, Aduriz
Albania: Berisha; Hysaj, Veseli, Ajeti, Memolla; Balliu, Kace, Memushaj; Xhaka, Llullaku, Grezda
Subs: Basha, Lila, Ahmedi, Kolici, Ndoj, Lenjani, Latifi, Agoli, Sadiku, Djimsiti, Hoxha I
Referee: Eskov (RUS)