The second Clasico of the season between Barcelona and Real Madrid will be played on Saturday April 2 at 19:30 GMT.
Similar to their first meeting at the Santiago Bernabeu in November, the Camp Nou encounter will be played after a two-week international break, during which time Spain will face Italy and Romania.
The first lot of Champions League quarter-final first legs are also due to be contested just three days later, on April 5, with Barca and Madrid all-but-certain to be involved.
Elsewhere in Week 31 of La Liga, the round begins with Getafe-Rayo Vallecano (19:30) on Friday and ends on Monday, when Levante host Sporting Gijon (19:30).
Saturday kicks off with Atletico Madrid-Real Betis at 15:00, before Celta Vigo and Deportivo La Coruna lock horns in a Galician derby at 21:05.