Cristiano Ronaldo, Karim Benzema, James Rodriguez and Isco all start as Real Madrid make the journey to Granada.
Zinedine Zidane names the same XI that routed Espanyol a week ago, with Keylor Navas behind Dani Carvajal, Raphael Varane, Sergio Ramos and Marcelo.
Toni Kroos and Luka Modric are in midfield with Isco and James rounding out the midfield and Ronaldo and Benzema the main attacking outlets.
Granada go with Andres Fernandez in goal and a defence containing Dmitri Foulquier, David Lomban, Ricardo Costa and Miguel Lopes.
Fran Rico and Ruben Perez are in the midfield with Isaac Success, Ruben Rochina and Adalberto Penaranda supporting David Barral.
Granada have both Isaac Cuenca and Abdoulaye Doucoure on the bench, the latter, like Penaranda, on loan from sister club Watford, Penaranda having been signed by the Hornets on transfer deadline day and immediately sent back to Los Carmenes.
Granada: Andres; Foulquier, Lomban, Costa, Lopes; Rico, Perez; Success, Rochina, Penaranda; Barral
Subs: Jesus Fernandez, Biraghi, Babin, El-Arabi, Doucoure, Cuenca, Krhin
Real Madrid: Navas; Carvajal, Varane, Ramos, Marcelo; Isco, Modric, Kroos, James; Ronaldo, Benzema
Subs: Casilla, Nacho, Casemiro, Kovacic, Arbeloa, Lucas Vazquez, Jese
Referee: Gil Manzano