Cesc Fabregas makes his 100th appearance for Spain tonight as La Roja conclude their Euro 2016 qualifying campaign with a trip to Ukraine.
The Chelsea midfielder is also given the captain's armband to mark becoming a centurion, in what is an all-changed XI named by Vicente del Bosque.
Elsewhere, late call-ups Mario Gaspar and Xabier Etxeita are handed their international debuts, while Kiev marks Thiago Alcantara's first cap in over a year.
Ukraine, on the other hand, can still achieve a runners-up spot in Group C, providing they better Slovakia's result against Luxembourg.
Ukraine: Pyatov; Fedetskiy, Kucher, Rakitskiy, Shevchuk; Rotan, Stepanenko; Yarmolenko, Garmash, Konoplyanka; Kravets
Subs: Boyko, Shevchenko, Pylyavskyi, Kamenyuka, Tymoshchuk, Malinovskiy, Gusev, Zinchenko, Rybalka, Karavayev, Seleznyov, Budkivskiy
Spain: De Gea; Mario, Nacho, Etxeita, Azpilicueta; San Jose, Cesc; Isco, Thiago, Nolito; Alcacer
Subs: Casillas, Rico, Pique, Bartra, Juanfran, Alba, Busquets, Mata, Cazorla, Pedro
Referee: Mazic [SRB]