Spain are likely to start their Euro 2016 qualifier against Belarus on Sunday without Isco or Koke.
According to AS, Vicente del Bosque opted for a midfield trio of Sergio Busquets, Cesc Fabregas and Santi Cazorla, the latter of whom has spent much of the season playing in a deeper role for Arsenal, in training.
Elsewhere, Iker Casillas should replace David de Gea in goal, while Juanfran and Jordi Alba are expected to come in for Dani Carvajal and Juan Bernat.
In attack, Pedro Rodriguez is likely to replace Nolito on the left of La Roja’s trident, with an injury to Aleix Vidal seeing David Silva enter the fray on the opposite flank.
Spain’s match against Belarus will be played in Borisov, an hour-and-15 minutes away from their team hotel in Minsk.
The European champions need a win in order to stay hot on the trail of Slovakia, who lead Group C by three points with five games remaining.
Probable line-up: Casillas; Juanfran, Ramos, Pique, Alba; Busquets, Cesc, Cazorla; Silva, Morata, Pedro