Jese has missed out on a place in the Spain senior side for the friendly with Italy but is included in the Under-21 squad.
The forward is joined by Real Madrid teammates Isco, Alvaro Morata and Dani Carvajal, while Barcelona winger Gerard Deulofeu, on loan at Everton, is also involved after recovering from injury.
It had been rumoured Jese would be included in the senior squad to play Italy.
La Rojita play Germany and Coach Julen Lopetegui can also call on Sevilla’s Alberto Moreno, who was in the senior squad to play South Africa in November.
Spain Under-21 squad to face Germany: Kepa, Pacheco; Carvajal, Amat, Derik Osede, S. Gómez, Bernat, A. Moreno; S. Roberto, Isco, R. Pardo, Denis Suárez, Saúl Ñíguez, Deulofeu; Morata, Jesé, Muniain, Sarabia,
