Spain have made a host of changes from the side that beat Equatorial Guinea on Saturday, as they prepare to face South Africa.
Vicente del Bosque’s men return to Johannesburg for the first time since they won the 2010 World Cup.
And will do so with Iker Casillas back in goal in place of Pepe Reina, as Raul Albiol, Sergio Ramos, Alvaro Arbeloa and Nacho Monreal all come in at the back.
Xabi Alonso keeps his place after recovering from an ankle knock, with Barcelona pair Sergio Busquets and Andres Iniesta coming in alongside the 31-year-old.
Fernando Llorente replaces Alvero Negredo as the main striker, with David Villa and Pedro playing as the other two forward.
South Africa: Khune, Ngconga, Khumalo, Nthete, Matlaba, Furman, Jali, Manyisa, Claasen, Parker, Rantie
Spain: Casillas, Arbeloa, Albiol, Ramos, Monreal, Busquets, Alonso, Iniesta, Pedro, Llorente, Villa