Barcelona have opted to start with Alex Song and Adriano at centre-back for the match against Rayo Vallecano.
Tito Vilanova will start with the Cameroon international and the former Sevilla man in the centre of defence following the injuries to Gerard Pique and Carles Puyol and the suspension being served by Javier Mascherano.
Elsewhere, Martin Montoya plays at right-back, whilst Xavi, Cesc Fabregas and Sergio Busquets start in midfield.
Lionel Messi, Pedro and David Villa will play in a front-three.
For Rayo, Andrija Delibasic and Leo Baptistao start up front as the Franjirrojos look to move into the top half of the table
Rayo Vallecano: Ruben; Tito, Rodri, Amat, Casado; Jose Carlos, Javi Fuego, Piti, Chori; Delibasic, Leo
Barcelona: Valdes; Montoya, Song, Adriano, Alba; Xavi, Busquets, Fabregas; Pedro, Messi, Villa