Real Madrid begin the defence of their La Liga crown with a home game against Valencia on the first weekend of the new season.
Rivals Barcelona, meanwhile, also kick off on home turf and entertain Real Sociedad, with the first El Clasico set for October 7 in the Camp Nou and the return at the Santiago Bernabeu pencilled in for the 26th round of fixtures on March 3, 2013.
Of the promoted teams, Celta Vigo face Malaga at Balaidos while Deportivo de La Coruna also have a home fixture when they take on Osasuna, with Real Valladolid travelling to La Romareda for a game against Real Zaragoza.
The full list of fixtures for the opening weekend of August 18-19 is:
Athletic Bilbao-Real Betis
Real Zaragoza-Real Valladolid
Deportivo de La Coruna-Osasuna