The Champions League Round of 16 draw took place on Monday morning with all four remaining Spanish sides discovering their fate.
Real Madrid are involved in the tie of the round as they have been paired with England champions Manchester City, who they last played in the semi-finals of the 2016 competition.
Barcelona will face Italian side Napoli while Valencia will also be favourites against Italian opposition – Los Che have been paired with Atalanta, who are at this stage for the first time in their history.
Atletico Madrid have been handed a daunting draw as they have been pitted against competition holders Liverpool.
The first leg of the ties will take place across the 18-19 and 25-26 February, with the return legs being played across the 10-11 and 17-18 March.
The final this year will be played at Atatürk Olympic Stadium, Istanbul.
Champions League draw:
Real Madridv Manchester City
Atalanta v Valencia
Atletico Madrid v Liverpool
Napoli v Barcelona
Dortmund v Paris Saint-Germain
Chelsea v Bayern Munich
Lyon v Juventus
Tottenham v RB Leipzig