Barcelona boss Ernesto Valverde makes five changes to the side that one that beat Sevilla 4-0 in their last La Liga game.
Ousmane Dembele and Gerard Pique are both suspended, with Antoine Griezmann and Samuel Umtiti coming in to replace them.
Jordi Alba returns at left back, with Nelson Semedo dropping out, and Clement Lenglet and Sergio Busquets in for Arturo Vidal and Jean-Clair Todibo in defence and midfield.
Eibar manager Jose Luis Menilibar also shuffles his side, with five changes from the 1-1 draw at Real Betis before the international break.
Charles de Oliveira and Sergi Enrich return to lead the attack, with Sergio Alvarez and Pedro Leon in midfield and Cote at left back,
EIBAR: Dmitrovic, De Blasis, P. Oliveira, Arbilla, Cote, Leon, Alvarez, Diop, Orellana, Enrich, C. Oliveira
SUBS: Yoel, Bigas, Gonzalez, Exposito, Garcia, Inui, Tejero
BARCELONA: Ter Stegen, Roberto, Umtiti, Lenglet, Alba, Busquets, De Jong, Arthur, Messi, Suarez, Griezmann
SUBS: Neto, Semedo, Todibo, Rakitic, Vidal, FAti, Perez