Real Madrid boss Zinedine Zidane makes wholesale changes to the side that won 1-0 at Sevilla this weekend.
Los Blancos host Osasuna in midweek La Liga action, and the Frenchman only retains three players from the starting XI from the weekend, with only Sergio Ramos, Toni Kroos and Casemiro remaining.
Alphonse Areola makes his first appearance in goal, after joining in a deadline day deal from PSG, replacing Thibaut Courtois.
Ramos is joined in defence by Eder Militao, Alvaro Odriozola an Nacho Fernandez, in place of Raphael Varane, Dani Carvajal and the injured Ferland Mendy.
In midfield, Fede Valverde is in for James Rodriguez, with Vinicius Junior, Luka Jovic and Lucas Vazquez replacing Gareth Bale, Karim Benzema and Eden Hazard in attack.
Osasuna are unbeaten in their first five games of the 2019-20 La Liga season, following their return to the top flight, four successive draws ahead of their trip to the Santiago Bernabeu.
Manager Jagoba Arrasate makes seven changes from the side that drew 0-0 at home to Real Betis at the weekend, with Raul Navas, Marc Cardona, Brandon, Facundo Roncaglia, Ruben Garcia, Lillo, Robert Ibanez and Jon Moncayola coming in for Nacho Vidal, David Garcia, Oier Sanjuro, Aridane, Roberto Torres, Adrian and Ezequiel Avila.
REAL MADRID: Areola, Militao, Ramos, Nacho, Odriozola, Casemiro, Kroos, Valverde, Vinicius, Jovic, L.Vazquez
SUBS: Courtois, Carvajal, Varane, Rodriguez, Hazard, Rodrygo, Benzema
OSASUNA: Ruben, Navas, Roncaglia, Lillo, Estupinan, Cardona, Merida, Garcia, Brandon, Moncayola, Ibanez
SUBS: Piron, Vidal, Torres, Avila, Vazquez, Perea, J.Hernandez