Arturo Vidal starts for Barcelona against an Atletico Madrid side who are without three of their first-choice defenders.
Vidal replaces the injured Ivan Rakitic in Barca's midfield, the Croat having picked up a hamstring injury while representing Croatia on international duty.
Elsewhere, Nelson Semedo comes in at right-back, allowing Sergi Roberto to partner Lionel Messi and Luis Suarez up top in Philippe Coutinho's continued absence.
And despite reports of ill-discipline over the past week, Ousmane Dembele makes up a strong bench with the likes of Rafinha, Malcom and Clement Lenglet.
Atleti, for their part, are robbed of Juanfran Torres, Josema Gimenez and Diego Godin, so Filipe Luis is joined by Santiago Arias, Lucas Hernandez and Stefan Savic in defence.
Antoine Griezmann and Diego Costa lead their forward line, hoping to add to their combined tally of four League goals.
Diego Simeone has yet to beat the Blaugrana in La Liga, with Los Colchoneros' last win coming back in February 2010.
Atletico Madrid: Oblak; Arias, Savic, Lucas Hernandez, Filipe; Koke, Rodri, Saul, Lemar; Costa, Griezmann
Subs: Adan, Thomas, Kalinic, Correa, Gelson, Vitolo, Toni
Barcelona: Ter Stegen; Semedo, Pique, Umtiti, Alba; Vidal, Busquets, Arthur; Sergi Roberto, Messi, Suarez
Subs: Dembele, Rafinha, Cillessen, Malcom, Lenglet, Munir, Alena
Referee: Gil Manzano