Sergio Busquets and Luis Suarez are missing for Barcelona against Athletic Bilbao, who surprisingly bench Inaki Williams and Aritz Aduriz.
Busquets is out with a broken toe and Suarez is suspended after accumulating five yellow cards, and taking their places in the Barca XI are Paulinho and Paco Alcacer.
Nelson Semedo and Denis Suarez also remain on the treatment table, so there are places in the squad for defender Yerry Mina and B midfielder Carles Alena.
Athletic, meanwhile, drop top scorer Aduriz for the second Liga game running, while Williams is also named a substitute, despite the Basques having nothing else to play for after their Europa League elimination midweek.
Blaugurana boss Ernesto Valverde coached Athletic for four years, before succeeding Luis Enrique last summer, and won 2-0 in his first reunion with the Basques earlier in the campaign.
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Barcelona: Ter Stegen; Sergi Roberto, Pique, Umtiti, Alba; Dembele, Rakitic, Paulinho, Coutinho; Messi, Alcacer
Subs: Iniesta, Cillessen, Digne, Gomes, Vidal, Yerry Mina, Alena
Athletic Bilbao: Kepa; Saborit, Inigo, Nunez, De Marcos; Benat, San Jose; Lekue, Raul Garcia, Susaeta; Sabin
Subs: Herrerin, Iturraspe, Williams, Etxeita, Aduriz, Vesga, Cordoba
Referee: Jaime Latre