Real Madrid travel to Real Betis on the back of their Champions League win over Paris Saint-Germain in midweek.
Madrid were victorious against PSG but find themselves a huge 20 points adrift of League leaders Barcelona having played two games fewer than the Catalans.
Zinedine Zidane’s side are fourth in the table, four points behind third-place Valencia and 13 short of city rivals Atletico Madrid, with two games in hand on both Los Che and Los Rojiblancos.
Ninth-place Betis, meanwhile, are comfortably mid-table, 15 points clear of the relegation zone and with an eye on the European places with just a four-point gap from Villarreal in sixth.
Quique Setien’s side beat the Yellow Submarine in early February and took a 1-0 win over Deportivo La Coruna at Riazor in their last outing, and also beat Madrid at Santiago Bernabeu in September, Tonny Sanabria getting the only goal of the game.
The last time Madrid were at Benito Villamarin, however, saw Los Blancos put six goals past their hosts with only one coming in reply. Isco scored twice and Raphael Varane, Karim Benzema, Marcelo and Cristiano Ronaldo were all on the score sheet for the visitors.