Luka Modric is benched for Real Madrid's clash with Las Palmas this evening, while young defender Jesus Vallejo makes his League debut.
Modric has paid the price for two disappointing displays against Girona and Tottenham Hotspur, with Isco dropping into central midfield.
Consequently, Zinedine Zidane reverts to a 4-3-3 formation as Karim Benzema is flanked by Cristiano Ronaldo and newcomer Marco Asensio.
Vallejo is also called for the first time since appearing in the Copa del Rey against third-tier Fuenlabrada last month, partnering Sergio Ramos in the heart of defence.
Gareth Bale and Dani Carvajal, however, are not included, despite the pair returning to training, and join Mateo Kovacic, Keylor Navas and Raphael Varane in missing the match.
Reports, meanwhile, suggest Las Palmas have already contacted former Atletico Madrid, Osasuna and Real Zaragoza boss Javier Aguirre about replacing Pako Ayestaran, in the event the latter fails to mastermind the islanders to a shock victory.
Ayestaran has set a new League record of 11 consecutive defeats across his spells with Las Palmas and Valencia, and his cause has not been helped by Aythami Artiles, Tana, Jonathan Viera, Alen Halilovic and Ousmane Tannane all pulling out with injury.
However, the visitors can take solace from drawing with Los Blancos twice last season and scoring five goals against them.
Real Madrid: Casilla; Nacho, Vallejo, Ramos, Marcelo; Kroos, Casemiro, Isco; Asensio; Ronaldo, Benzema
Subs: Modric, Theo, Vazquez, Marcos Llorente, Mayoral, Ceballos, Moha
Las Palmas: Lizoain; Michel, Ximo, Lemos, Bigas, Dani Castellano; Vicente, Javi Castellano, Aquilani; Calleri, Vitolo
Subs: David Garcia, Samper, Remy, Momo, Chichizola, Hernan, Borja Herrera
Referee: Sanchez Martinez