Zinedine Zidane names Casemiro in the centre of defence with Sergio Ramos banned as Real Madrid host Valencia.
Ramos was sent off last weekend at Deportivo La Coruna and deprived of other options, Zidane pushes midfielder Casemiro into the back four, partnering Nacho.
Keylor Navas continues in goal with Dani Carvajal and Marcelo rounding out the home team’s defence.
Luka Modric and Toni Kroos are joined in midfield by Isco and Marco Asensio, with Karim Benzema and Gareth Bale in attack as Cristiano Ronaldo remains suspended.
Valencia have Neto in goal and a debutant in defence as Jeison Murillo returns to La Liga following his move from Inter.
The ex-Granada man is joined in the back four by Martin Montoya, Ruben Vezo and Toni Lato and is one of four changes to the XI that beat Las Palmas
Geoffrey Kondogbia, formerly of Sevilla and also arriving at Valencia via Inter, features in midfield with Jose Gaya, Dani Parejo and Carlos Soler.
Rodrigo Moreno and Simone Zaza lead the line for the visitors.
Real Madrid: Navas; Carvajal, Nacho, Casemiro, Marcelo; Asensio, Modric, Kroos, Isco; Bale, Benzema
Subs: Casilla, Theo, Lucas Vazquez, Llorente, Borja Mayoral, Kovacic, Ceballos
Valencia: Neto; Montoya, Vezo, Murillo, Lato; Soler, Parejo, Kondogbia, Gaya; Rodrigo, Zaza
Subs: Domenech, Jimenez, Maksimovic, Mina, Medran, Vidal, Gil