Arda Turan replaces the suspended Neymar for Barcelona against an attack-minded Atletico Madrid, who are similarly without captain Gabi Fernandez.
Neymar and Gabi both picked up yellow-card bans at the Vicente Calderon last week, their places taken by Arda and Yannick Carrasco respectively.
Five other changes for Barca, meanwhile, see first-team trio Jordi Alba, Sergi Roberto and Luis Suarez back in their line-up.
Atleti, on the other hand, go with a supercharged 4-4-2 formation, with Juanfran Torres returning to right-back, Carrasco in front of him and Nico Gaitan occupying the opposite wing.
Barca are 2-1 up from the first leg in this Copa del Rey semi-final and can make it three straight finals under Luis Enrique.
Barcelona: Cillessen; Sergi, Pique, Umtiti, Alba; Rakitic, Gomes, Denis; Messi, Suarez, Arda
Subs: Masip, Busquets, Iniesta, Mascherano, Alcacer, Digne, Vidal
Atletico Madrid: Moya; Juanfran, Godin, Savic, Filipe; Koke, Saul, Gaitan, Carrasco; Griezmann, Torres
Subs: Moreira, Lucas, Vrsaljko, Thomas, Moreno, Correa, Gameiro
Referee: Gil Manzano