Raphael Varane and Isco come in to the Real Madrid XI to play Valencia as Iker Casillas bides his time on the bench.
Carlo Ancelotti had previously confirmed that Casillas would return to League action before the end of the season and is in line to start against Real Valladolid in midweek.
There are changes, however, as Raphael Varane, Marcelo, Asier Illarramendi and Isco all come in to the side. Pepe, Fabio Coentrao, Luka Modric and Angel Di Maria drop out.
Coentrao and Di Maria are with Casillas among the reserves, where they are joined by Sami Khedira, who has been out injured since November.
Valencia make two changes from the side that beat Sevilla 3-1 in the Europa League semi-final second-leg in midweek, Javi Fuego and Paco Alcacer coming in.
Pablo Piatti and Jonas are the players to miss out after Los Che bowed out of Europe due to Stephane Mbia’s late goal.
A win for Los Blancos would see them move level on points with Barcelona, three behind leaders Atletico Madrid, who were beaten earlier today by Levante.
Valencia would leapfrog Celta Vigo with a win at Santiago Bernabeu, four points behind seventh-place Villarreal, depending on the outcome of the Yellow Submarine’s trip to Sevilla.
Real Madrid: Diego Lopez; Carvajal, Sergio Ramos, Varane, Marcelo; Illarra, Xabi Alonso, Isco; Bale, Cristiano, Benzema
Valencia: Alves; Joao, R. Costa, Mathieu, Bernat; J. Fuego, Keita; Feghouli, D. Parejo, Vargas; Alcacer