Tata Martino has rung the changes to the Barcelona side that beat Real Madrid on Sunday.
Out go Dani Alves, Gerard Pique, Sergio Busquets and Xavi Hernandez from the XI to face Celta Vigo – with Adriano, Marc Bartra, Alex Song and Alexis Sanchez coming in.
That would appear to mean Cesc Fabregas will revert to a midfield position with Lionel Messi supported by Alexis and Neymar, who keeps his place.
Victor Valdes captains the side in the absence of Carles Puyol and Xavi, who has dropped out of the squad altogether. Alves, Pique and Busquets are on the bench, as is Pedro.
They are joined by goalkeeper Jose Pinto, Sergi Roberto and Christian Tello.
Celta are without on-loan Barca forward Rafinha, who misses out through injury, while former Barca player Luis Enrique doesn’t call on Charles or Nolito either.
Both players are named among the Celta substitutes with 18-year-old Santiago Mina brought into the attack instead.
Yoel is in goal for Os Celestes with the back four made up of Hugo Mallo, Gustavo Cabral, Jon Aurtenetxe and Jonny.
Former Barca youngster Andreu Fontas has been named in midfield with Levy Madinda and Alex Lopez.
Augusto Fernandez, Fabian Orellena and the youngster Mina complete the visiting team.
Barcelona: Valdes; Adriano, Mascherano, Bartra, Alba; Song, Cesc, Iniesta; Alexis, Messi, Neymar
Celta: Yoel, Mallo, Cabral, Aurtenetxe, Jonny; Fontas, Madinda, Lopez; Fernandez, Orellena, Mina