Jese replaces the injured Gareth Bale as Real Madrid attempt to become the first League visitors to beat Athletic Bilbao at San Mames.
Diego Lopez continues in goal for Carlo Ancelotti’s side with Dani Carvajal and Marcelo again preferred to Alvaro Arbeloa and Fabio Coentrao on either side of the back four.
Sergio Ramos and Pepe complete the defence, a pairing that has yet to concede a League goal in the calendar year of 2014.
Ancelotti persists with a 4-3-3 formation, again selecting Xabi Alonso, Luka Modric and Angel Di Maria as the trio.
Cristiano Ronaldo and Karim Benzema complete the attacking unit.
Ernesto Valverde has Gorka Iraizoz in goal with a back four of Oscar De Marcos, Carlos Gurpegi, Aymeric Laporte and Mikel Balenziaga.
Ander Iturraspe and Mikel Rico form the midfield axis with Markel Susaeta, Ander Herrera and Iker Muniain behind Aritz Aduriz.
Athletic: Iraizoz; De Marcos, Gurpegi, Laporte, Balenziaga; Iturraspe, Mikel Rico; Susaeta, Herrera, Muniain; Aduriz
Madrid: Diego Lopez; Carvajal, Pepe, Ramos, Marcelo; Xabi Alonso, Modric, Di Maria; Jese, Ronaldo, Benzema