At home to Real Valladolid, this is a game Osasuna and Jose Luis Mendilibar really can't afford to lose, or even draw.
Los Rojillos are rock bottom of La Liga with just five points and one win to their name and it's hard to envision Mendilibar keeping his job for much longer if they don't pick up.
“We are in a difficult moment,” concedes 'keeper Asier Riesgo. “Against Valladolid we must push and try to win. Everyone's struggling away from home, but home is where you cannot drop any points.”
Newly promoted Valladolid are 10 points and five positions better off but Coach Miroslav Djukic is still furious with their form, expressing his discontent on Monday despite his side coming from behind twice to draw 2-2 wth Real Sociedad.
“We were awful. We were insecure and played without thinking. The only good thing was the point.”
Kick off: Sunday November 4, 4.50 (BST)