Barcelona manager Ernesto Valverde has five recalled players to the Barcelona starting line up from their midweek Copa del Rey win over Sevilla.
Marc Ter Stegen replaces the injured Jesper Cillessen, and Nelson Semedo, Thomas Vermaelen Carles Alena and Arturo Vidal, are in for Jordi Alba, Clement Lenglet, Arthur and Sergio Busquets - who is suspended.
Valencia bring Neto, Jose Gaya, Francis Coquelin, Denis Cheryshev and Kevin Gameiro into their starting XI following their own Copa del Rey win against Getafe.
BARCELONA: Ter Stegen, Semedo, Pique, Lenglet, Roberto, Alena, Vidal, Rakitic, Coutinho, Messi, Suarez
SUBS: Pena, Arthur, Lenglet, Malcom, Alba, Murillo, Boateng
VALENCIA: Neto, Piccinini, Garay, Paulista, Grueso, Wass, Coquelin, Parejo, Cheryshev, Rodrigo, Gameiro
SUBS: Jaume, Roncaglia, Kondogbia, Soler, Lee, Torres, Mina