And it’s a big game for La Blaugrana, who’ll be keen to bounce back from consecutive defeats against Eintracht Frankfurt in the Europa League and Cadiz in La Liga.
Both of those reverses came at home and Xavi Hernandez will hope that the road can provide his men sweet relief.
But it’s not going to be an easy game.
Barcelona are facing a team that have been quietly and competently building an outside challenge for the top four.
La Real are currently sixth in La Liga, two points behind fifth-placed Real Betis and five behind Atletico Madrid, Sevilla and Barcelona, who are all tied for points.
Xavi will be determined his men put their recent issues behind them and has spoken sternly with the players about Monday night’s defeat in particular.
He wants to see new attitudes from each of his players.
“They can’t beat us in faith and desire,” he said in his pre-match press conference as carried by Diario Sport.
“We have to get excited again. It’s hard to do this when our goal is second place in La Liga but this is our reality. We must engage the fans. Great stories are written with a good beginning.
“We’ve entered an emergency dynamic; now we have to reset.”