Los Che return to domestic action following the current international break with a crunch journey up the coast as Jose Bordalas’ side aim for a first league win since early September.
Cheryshev and Gaya have missed Valencia’s last league four games with Soler sidelined for their last three matches with a knee problem.
The trio are all expected to be included in the travelling party to the Camp Nou with Bordalas willing to bring them straight back into the starting XI.
POSSIBLE VALENCIA STARTING XI V BARCELONA
Cillessen: Diakhaby, Paulista, Guillamon, Gaya; Soler, Wass, Racic; Cheryshev, Guedes, Duro