The Brazilian winger has been drafted into the starting XI as boss Ronald Koeman battles against an injury crisis in Catalonia this month.
The Dutchman makes four changes to his first XI following their Champions League defeat to Bayern Munich last time out.
Kick off at the Camp Nou is at 9pm local time and a win for Koeman will bring La Blaugrana up to at least 4th in the table overnight.
BARCELONA STARTING XI V GRANADA
Ter Stegen; Dest, Araujo, Garcia, Balde; Roberto, Busquets, De Jong; Coutinho, Memphis, Demir