Neither side have created much on the night with injuries dominating the first 45 minutes at the Estadio Mestalla.
Los Blancos defender Dani Carvajal was also taken off before the half hour mark.
The tempo of the match has not improved much after the restart with Duro grabbing the one real chance of the second period.
The former Los Blancos loanee failed to make an impact at the club last season but he has netted his first goal for Valencia after another season long loan exit from Getafe this summer.
A goal worth celebrating with the #LaLigaFanCam! 🔥
— LaLigaTV (@LaLigaTV) September 19, 2021
Valencia's resurgence continues! 🦇
Fantastic technique from Hugo Duro and, as things stand, Los Che will be headed to the top of LaLiga if they can hang on for a win over Madrid 🔥 pic.twitter.com/dF5isSGJoA
— Premier Sports (@PremierSportsTV) September 19, 2021
Carlo Ancelotti has reacted by making four substitutes to try and force Real Madrid back into it and preserve their unbeaten record in 2021/22.
Images via Getty Images