La Roja face the Slovakians needing a win at the Estadio de La Cartuja in order to secure their place in the last 16.
Enrique has opted to make just one change to his starting line up from their successive draws against Sweden and Poland with Alvaro Morata keeping his place in the No.9 role.
Captain Sergio Busquets looks certain to replace Rodri at the base of the midfield, with the defence and goal keeper slots remaining unchanged.
One of Morata or Moreno will drop out of the starting team with Manchester City winger Ferran Torres replacing whoever is rotated out by Enrique.
The final slot in La Roja’s attacking trio is up for debate with Adama Traore or Mikel Oyarzabal battling Dani Olmo for the No.11 position in Sevilla.