The trio missed the midweek Champions League defeat to Chelsea and Simeone will not rush them back into first team action.
Trippier can return to first team training next week following his FIFA suspension, but Gimenez and Carrasco are still another week away from returning due to injuries.
Simeone is likely to rotate his starting team against Unai Emery’s hosts, with Sime Vrsaljko and Renan Lodi potentially in line to return to the first XI.
POSSIBLE ATLETICO MADRID STARTING XI V VILLARREAL
Oblak; Savic, Hermoso, Felipe; Vrsaljko, Koke, Llorente, Lemar, Lodi; Suarez, Correa