Key defensive duo Sergio Ramos and Dani Carvajal are both missing through injury while Raphael Varane and Toni Kroos also rested for the trip, but all of the other usual starters are included for the trip.
One of the biggest surprises is the absence of Martin Odegaard – who is not included in the squad despite no reports of an injury, having not featured in 10 matches.
— Real Madrid C.F. (@realmadrid) January 19, 2021
Lucas Vazquez has started in 16 successive matches, Thibaut Courtois has been ever-present all season while Toni Kroos has played 14 games in a row and Karim Benzema has started 10 on the bounce after recovering from an injury.
Eder Militao, Nacho Fernandez, Marcelo, Alvaro Odriozola and Mariano Diaz are among the fringe players who will be hoping for minutes.
Madrid are overwhelming favourites for the tie, although Alcoyano did knock out La Liga outfit Huesca in the previous round.
Real Madrid squad list:
Goalkeepers: Courtois, Lunin, Altube
Defenders: E. Militão, Nacho, Marcelo, Odriozola, F. Mendy, Chust
Midfielders: Kroos, Casemiro, Valverde, Isco, Blanco
Attackers: Hazard, Benzema, Asensio, Lucas V., Vinicius Junior, Mariano Diaz