Sevilla have already secured their place in the last 16, finishing as runners up to group winners Chelsea, unless there is a dramatic goal swing against Frank Lampard’s side in their final game.
Lopetegui will leave club captain Jesus Navas in Spain, alongside midfield pair Joan Jordan and Munir El Haddadi, with the latter struggling with an ongoing hamstring injury.
— Sevilla Fútbol Club (@SevillaFC) December 6, 2020
Goalkeeper Tomas Vaclik has been ruled through injury, with Yassine Bounou set to continue as his replacement, according to reports from Marca.
Full back pair Marcus Acuna and Sergio Escudero are also out, with Lopetegui expected to make wholesale changes to the team that started in their 1-0 La Liga defeat to Real Madrid this weekend.
POSSIBLE SEVILLA STARTING XI V RENNES
Bono; Gomez, Rekik, Kounde, Carlos, Rekik; Rakitic, Fernando, Gudelj; Vazquez, En-Nesyri, Idrissi