Gerard Pique makes his 500th club appearance for FC Barcelona as they take on Real Betis at the Camp Nou.
The former Spanish international captains the team in the absence of Lionel Messi, with Antoine Griezmann making his first home start as a FC Barcelona player.
Ernesto Valverde makes three changes to the side that lost 1-0 at Athletic Bilbao on the opening day, with Rafinha, Sergi Roberto and Carles Perez replacing Carles Alena, Luis Suarez and Ousmane Dembele.
Real Betis boss Rubi is without star striker Borja Iglesias, and he is replaced by Loren Mouron.
Dani Martin, Antonio Pedraza, Andres Guardado and Sergio Canales also come into the starting up line up in place of Joel Robles, Javi Garcia, Alfonso and Joaquin.
FC BARCELONA: Ter Stegen, Semedo, Pique, Sergio, Rafinha, Lenglet, Griezmann, Alba, Roberto, De Jong,Perez
SUBS: Peña, Rakitic, Arthur, Vidal, Umtiti, Junior Firpo, Ansu Fati
REAL BETIS: Martin, Emerson, Bartra, Sidnei, Pedraza, Carvalho, Guardado, Canales, Fekir, Tello, Loren
SUBS: Rebollo, Mandi, Garcia, Kaptoum, Joaquin, Lainez, Juanmi